Scientists at Michigan State University may have found a promising new treatment that can stop the spread of melanoma by 90 percent.
Small-molecule drugs take up 90 percent of drugs in the market. The researchers at Michigan State University work on developing a small-molecule drug that has the ability to stop the spread of melanoma in the body.
Melanoma cytology field stain
The compound stops the production of the RNA molecules and some proteins in the melanoma tumors. This activity triggers the transcription process which then leads to the activation of a protein called RhoC, or Ras homology C. The protein leads the pathway to the progression of the disease all over the body.
"Melanoma is the most dangerous form of skin cancer with around 76,000 new cases a year in the United States," said Kate Appleton, co-author of the study.
"One reason the disease is so fatal is that it can spread throughout the body very quickly and attack distant organs such as the brain and lungs."
The team found that the drug reduced the spread of melanoma tumors by 85 to 90 percent. It became apparent when the drug greatly reduced the tumors specifically in the lungs of mice which had been injected with human melanoma cells.
The scientists have to monitor the locations of RhoC pathways for a targeted treatment.
"The effect of our compounds on turning off this melanoma cell growth and progression is much stronger when the pathway is activated," Appleton said.
"We could look for the activation of the MRTF proteins as a biomarker to determine risk, especially for those in early-stage melanoma."
Richard Neubig, a pharmacology professor and co-author of the study said that if melanoma disease is caught early, the chance of death is only 2 percent. If caught late, the chance of death rises at 84 percent.
The study is published in Molecular Cancer Therapeutics
See: Fluorescent Surgery Tattoo Made to Work For Skin Cancer Biopsy Treatments