Scientists highlight the possibility of breast cancer progression by looking out for the structural changes of the receptors responsible for regulating molecules linked to cancer growth.
It is important to know the behavior and predictability of anything that you want to fight off, and that can also apply to fighting cancer. Treatments and drugs will fare better with their results when medical experts know how cancer moves and grows.
Scientists at the Scripps Research Institute (TSRI) in Florida campus aims to know how the proliferation and non-proliferation of cancer by reading through structural changes of molecules and in doing so, structure-based drugs can be administered with high treatment potential.
The team at TSRI synthesized more than 240 molecule-binding estrogen receptors or ligands that leads to cancer proliferation. To find out the root of its binding properties, the team used structural analysis.
Certain drugs in the market decreases the ability of the estrogen receptor to block the proliferation of the cancer cells but negative side effects may also occur.
The study allows the experts to choose the best method with minimal ill effects in treating cancer.
“Our approach reveals some mechanisms associated with tissue specificity and several predictive structural features," said co-author Sathish Srinivasan.
Research associate Jerome Nwachukwu added, “We can predict some of these effects by measuring the distance between two specific carbon atoms of the estrogen receptor."
This structural predictability can help experts provide the best method for breast cancer treatment.
The study is published in the journal Molecular Systems Biology.
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